Dr. Gage manages the Radiation Oncology department, works directly with cancer patients to plan their specific treatment program. She was also a central figure in establishing, the Sibley Center for Breast Health and continues as a key member of the team, seeing patients and serving as the Education Coordinator. Most recently, Dr.Gage was an Assistant Professor of Oncology at The Johns Hopkins School of Medicine, as well as a staff physician at The Johns Hopkins Breast Center. She was a member of the oncology staff at the John Hopkins Hospital. Prior to Hopkins, Dr.Irene Gage was a faculty member at the Joint Center for Radiation Therapy at Harvard University School of Medicine. From 1993-1994, Dr. Gage was a clinical breast cancer fellow at Harvard, where she provided consultative services in breast cancer at the Dana Farber Institute and Beth Israel Hospital.

Dr. Gage received her M.D. degree in 1988 from Boston University. Her internship at Framingham Union Hospital was followed by a residency in radiation oncology at Tufts New England Medical Center. She is board certified by the American Board of Radiology in Radiation Oncology.